Publications

Independent Publications

64. Rosenblum, S. L.; Soueid, D. M.; Giambasu, G.; Vander Roest, S.; Pasternak, A.; DiMauro, E. F.; Simov, V.*; Garner, A. L.* “Live Cell Screening to Identify RNA-Binding Small Molecule Inhibitors of the pre-let-7-Lin28 RNA-Protein Interaction.” 2024, submitted.

63. Soueid, D.; Garner, A. L.* “Adaptation of RiPCA for the Live-Cell Detection of mRNA-Protein Interactions.” Biochemistry, 2023, 62, 3323-3336.

62. Soueid, D.; Garner, A. L.* “RNA-Protein Interactions: A New Approach for Drugging RNA Biology.” Methods and Principles in Medicinal Chemistry 2023, accepted.

61. Zhuang, Y.; Yang, F.; Menon, A.; Song, J. M.; Espinoza, R.; Schultz, P.; Garner, A. L.; Tripathi, A. “An ECD and NMR/DP4+ Computational Pipeline for Structural Revision and Elucidation of Diphenazine-Based Natural Products.” 2023, 86, 1801-1814.

60. Cárdenas, E. L.; O’Rourke, R. L.; Menon, A.; Meagher, J. L.; Stuckey, J. A.; Garner, A. L.* “Design and Synthesis of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E).” J. Med. Chem. 2023, 66, 10734-10745.

59. Torrez, R. M.; Nagaraja, S.; Menon, A.; Chang, L.; Ohi, M. D.; Garner, A. L. “Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a pre-microRNA and snoRNA.” Biochemistry 2023, 62, 1725-1734.

58. Aldrich, J.; Allen, S.; Araujo, E.; Bronson, J.; Bryant-Friedrich, A.; Cyr, S. K.; DiMauro, E. F.; Dzierba, C.; Garner, A. L.; Georg, G.; Goodwin, N. C.; Haranahali, K.; Huang, R.; Leftheris, K.; May-Dracka, T. L.; Olson, M. E.; Blanco, M.-J. “Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).” ACS Med. Chem. Lett. 2023, 14, 345-349.

57. Aldrich, J.; Allen, S.; Araujo, E.; Bronson, J.; Bryant-Friedrich, A.; Cyr, S. K.; DiMauro, E. F.; Dzierba, C.; Garner, A. L.; Georg, G.; Goodwin, N. C.; Haranahali, K.; Huang, R.; Leftheris, K.; May-Dracka, T. L.; Olson, M. E.; Blanco, M.-J. “Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).” J. Med. Chem. 2023, 66, 3651-3655.

56. Garner, A. L. “Contemporary Progress and Opportunities in RNA-Targeted Drug Discovery.” ACS Med. Chem. Lett. 2023, 14, 251-259.

Included in the virtual special issue “New Enabling Drug Discovery Technologies – Recent Progress”

55. Torrez, R. M.; Ohi, M. D.; Garner, A. L. "Structural Insights into the Advances and Mechanistic Understanding of Human Dicer." Biochemistry 2023, 62, 1-16.

54. Rosenblum, S. L.; Garner, A. L. “Optimization of RiPCA for the Live-Cell Detection of Pre-microRNA-Protein Interactions.” ChemBioChem 2022, 23, e202200508.

53. Rosenblum, S. L.; Garner, A. L. “RiPCA: An Assay for the Detection of RNA-Protein Interactions in Live Cells.” Curr. Protoc. Chem. Biol. 2022, 2, e358.

52. Garner, A. L. “Nucleosides, Nucleotides and Nucleic Acids as Therapeutics: A Virtual Special Issue.” ACS Pharmacol. Transl. Sci. 2021, 4, 1714-1715.

51. Robertson, A. W.; Sandoval, J.; Mohamed, O. G.; Zhuang, Y.; Gallagher, E. E.; Schmidt, J. J.; Caratelli, L.; Menon, A.; Schultz, P. J.; Torrez, R. M.; Hay, C. L.; Bell, B. A.; Price, P. A.; Garner, A. L.; Tripathi, A. "Discovery of Surfactins as Inhibitors of microRNA Processing Using cat-ELCCA." ACS Med. Chem. Lett. 2021, 12, 878-886.

50. Garner, A. L.; Djuric, S. W. “RNA: Opening New Doors in Medicinal Chemistry, A Special Issue.” ACS Med. Chem. Lett. 2021, 12, 851-853.

49. Rosenblum, S. L.; Lorenz, D. A.; Garner, A. L. “A Live-Cell Assay for the Detection of pre-microRNA-Protein Interactions.” RSC Chem. Biol. 2021, 2, 241-247.

Selected as a 2021 Editors' Choice article
Highlighted by Promega Connections: https://www.promegaconnections.com/rna-protein-interactions-garner/

48. Garner, A. L.; Djuric, S. W. “RNA: Opening New Doors in Medicinal Chemistry.” ACS Med. Chem. Lett. 2020, 11, 1659-1660.

47. Gallagher, E. E.^; Menon, A.^; Chmiel, A. F.; Deprey, K.; Kritzer, J. A.; Garner, A. L. ”A Cell-Penetrant Lactam-Stapled Peptide for Targeting eIF4E Protein-Protein Interactions.” Eur. J. Med. Chem. 2020, 205, 112655. (^Shared Authorship)

46. Mitchell, D. C.; Menon, A.; Garner, A. L. “Cyclin-Dependent Kinase 4 Inhibits the Translational Repressor 4E-BP1 to Promote Cap-Dependent Translation During Mitosis-G1 Transition.” FEBS Lett., 2020, 594, 1307-1318.

Selected as the cover article

45. Sherman, E. J.; Mitchell, D. C.; Garner, A. L. “The RNA-Binding Protein SART3 Promotes miR-34a Biogenesis and G1 Cell Cycle Arrest in Lung Cancer Cells.” J. Biol. Chem. 2019, 294, 17188-17196.

44. Garner, A. L. "RNA-Targeted Drug Discovery: Moving Beyond Promiscuous Small Molecule Scaffolds." Fut. Med. Chem. 2019, 11, 2487-2490.

43. Song, J. M.; Gallagher, E. E.; Menon, A.; Mishra, L. D.; Garner, A. L. “The Role of Olefin Geometry in the Activity of Hydrocarbon Stapled Peptides Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E).” Org. Biomol. Chem. 2019, 17, 6414-6419.

42. Sherman, E. J.^; Lorenz, D. A.^; Garner, A. L. “A Click Chemistry-Mediated Complementation Assay for RNA-Protein Interactions.” ACS Comb. Sci. 2019, 21, 522-527. (^Shared Authorship)

41. Gallagher, E. E.^; Song, J. M.^; Menon, A.; Mishra, L. D.; Chmiel, A. F.; Garner, A. L. "Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins 4E-BP1 and eIF4G." J. Med. Chem. 2019, 62, 4967-4978. (^Shared Authorship)

40. Garner, A. L.; Lorenz, D. A.; Gallagher, E. E. “A Click Chemistry Assay to Identify Natural Product Ligands for pre-microRNAs.” Methods Enzymol. 2019, 623, 85-99.

39. Garner, A. L., Lorenz, D. A.^; Sandoval, J.^; Gallagher, E. E.; Kerk, S. A.; Kaur, T.; Menon, A. "Tetracyclines as Inhibitors of pre-microRNA Maturation: A Disconnection Between RNA Binding and Inhibition." ACS Med. Chem. Lett.2019, 10, 816-821. (^Shared Authorship)

38. Mitchell, D. C.; Menon, A.; Garner, A. L. “Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1.” Cell Chem. Biol. 2019, 26, 980-990.

37. Kaur, T.; Menon, A.; Garner, A. L. ”Synthesis of 7-Benzylguanosine Cap Analogue Conjugates for eIF4E Targeted Degradation.” Eur. J. Med. Chem. 2019, 166, 339-350.

36. Johnson, O. T.; Kaur, T.; Garner, A. L. " A Conditionally Fluorescent Peptide Reporter of Secondary Structure Modulation." ChemBioChem

2019, 20, 40-45.

Invited as part of the ChemBioTalents issue
Selected as a VIP manuscript and highlighted in ChemistryViews

35. Garner, A. L. "cat-ELCCA: Catalyzing Drug Discovery through Click Chemistry." Chem. Commun. 2018, 54, 6531-6539.

Invited as part of the Emerging Investigators issue

34. Lorenz, D. A.; Kaur, T.; Kerk, S. A.; Gallagher, E. E.; Sandoval, J. Garner, A. L. “Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction.” ACS Med. Chem. Lett. 2018, 9, 517-521.

Selected as the Featured cover article and ACS Editors' Choice article

33. Lorenz, D. A.; Vander Roest, S.; Larsen, M. J.; Garner, A. L. "Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small Molecule Ligands for pre-microRNAs." SLAS Discovery 2018, 23, 47-54.

Featured in C&E News, "The RNA Drug Hunters," 2017, November 27 issue, pg. 16-18.
Featured in The Scientist: https://www.the-scientist.com/lab-tools/drug-discovery-techniques-open-the-door-to-rna-targeted-drugs-65903

32. Lorenz, D. A.; Garner, A. L. " “Approaches for the Discovery of Small Molecule Ligands Targeting microRNAs.” Topics Med. Chem. 2018, 27, 79-110.

31. Song, J. M.; Menon, A.; Mitchell, D. M.; Johnson, O. T.; Garner, A. L. "High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions." ACS Comb. Sci. 2017, 19, 763-769.

Chosen as the cover article

30. Lorenz, D. A.; Garner, A. L. "A Click Chemistry-Based microRNA Maturation Assay Optimized for High-Throughput Screening." Chem. Commun. 2016, 52, 8267-8270.

Featured in The Scientist: https://www.the-scientist.com/lab-tools/drug-discovery-techniques-open-the-door-to-rna-targeted-drugs-65903

29. Hart, J. R.; Weinberg, M. S.; Morris, K. V.; Roberts, T. C.; Janda, K. D.; Garner, A. L.; Vogt, P. K. “MINCR is Not a MYC-Induced lncRNA.” Proc. Natl. Acad. Sci., U. S. A. 2016, 113, E496-E497.

28. Lorenz, D. A.; Song, J. M.; Garner, A. L. "High-Throughput Platform Assay Technology for the Discovery of pre-microRNA-Selective Small Molecule Probes." Bioconj. Chem. 2015, 26, 19-23.

Post-doctoral Publications

27. Hart, J. R.*; Garner, A. L.*; Yu, J.; Ito, Y.; Sun, M.; Ueno, L.; Rhee, J.-K.; Baksh, M. M.; Stefan, E.; Hartl, M.; Bister, K.; Vogt, P. K.; Janda, K. D. “An Inhibitor of MYC Identified in a Kröhnke Pyridine Library.” Proc. Natl. Acad. Sci., U. S. A. 2014, 111, 12556-12561. (*Co-First Authorship)

26. Garner, A. L.; Fullagar, J. L.; Day, J. A.; Cohen, S. M.; Janda, K. D. “Development of a High-Throughput Screen and Its Use in the Discovery of Streptococcus pneumoniae Immunoglobulin A1 Protease (IgA1P) Inhibitors.” J. Am. Chem. Soc. 2013, 135, 10014-10017.

25. Kravchenko, V. V.; Garner, A. L.; Mathison, J. C.; Seit-Nebi, A.; Yu, J.; Gileva, I. P.; Ulevitch, R. J.; Janda, K. D. “Facilitating Cytokine-Mediated Cancer Cell Death by Proteobacterial N-Acylhomoserine Lactones.” ACS Chem. Biol. 2013, 8, 1117-1120.

24. Fullagar, J. L.*; Garner, A. L.*; Struss, A. K.; Day, J. A.; Martin, D. P.; Cai, X.; Janda, K. D.; Cohen, S. M. “Antagonism of a Zinc Metalloprotease Using a Unique Metal-Chelating Scaffold: Tropolones as Inhibitors of P. aeruginosa Elastase.” Chem. Commun. 2013, 49, 3197-3199. (*Co-First Authorship)

23. Garner, A. L.; Yu, J.; Struss, A. K.; Kaufmann, G. F.; Kravchenko, V. V.; Janda, K. D. “Immunomodulation and the Quorum Sensing Molecule 3-Oxo-C12-Homoserine Lactone: The Importance of Chemical Scaffolding for Probe Development.” Chem. Commun. 2013, 49, 1515-1517.

22. Garner, A. L.; Struss, A. K.; Fullagar, J. L.; Agrawal, A.; Moreno, A. Y.; Cohen, S. M.; Janda, K. D. “3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.” ACS Med. Chem. Lett. 2012, 3, 668-672.

21. Li, Z.; Garner, A. L.; Gloeckner, C.; Janda, K. D.; Carlow, C. K. S. “Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy.” PLoS Negl. Trop. Dis. 2011, 5, e1411.

20. Garner, A. L.; Park, J.; Zakhari, J. S.; Lowery, C. A.; Struss, A. K.; Sawada, D.; Kaufmann, G. F.; Janda, K. D. “A Multivalent Probe for AI-2 Quorum Sensing Receptors.” J. Am. Chem. Soc. 2011, 133, 15934-15937.

Featured in ChemBioChem 2012, 13, 508-510.

19. Garner, A. L.; Janda, K. D. “A Small Molecule Antagonist of Ghrelin O-Acyltransferase (GOAT).” Chem. Commun. 2011, 47, 7512-7514.

18. Garner, A. L.; Gloeckner, C.; Tricoche, N.; Zakhari, J. S.; Samje, M.; Cho-Ngwa, F.; Lustigman, S.; Janda, K. D. “Design, Synthesis and Biological Activities of Closantel Analogues: Structural Promiscuity and Its Impact on Onchocerca volvulus.” J. Med. Chem. 2011, 54, 3963-3972.

17. Uckun, F. M.; Qazi, S.; Ozer, Z.; Garner, A. L.; Pitt, J.; Ma, H.; Janda, K. D. “Inducing Apoptosis in Chemotherapy-Resistant B-Lineage Acute Lymphoblastic Leukemia (ALL) Cells by Targeting GRP78/HSPA5, A Master Regulator of the Anti-Apoptotic Unfolded Protein Response (UPR) Signaling Network.” Br. J. Haematol. 2011, 153, 741-752.

16. Kirchdoerfer, R. N.; Garner, A. L.; Flack, C. E.; Mee, J. M.; Horswill, A. R.; Janda, K. D.; Kaufmann, G. F.; Wilson, I. A. “Structural Basis for Ligand Recognition and Discrimination of a Quorum-quenching Antibody.” J. Biol. Chem. 2011, 286, 17351-17358.

15. Garner, A. L.; Yu, J.; Struss, A. K.; Lowery, C. A.; Zhu, J.; Kim, S. K.; Park, J.; Mayorov, A. V.; Kaufmann, G. F.; Kravchenko, V. V.; Janda, K. D. “Synthesis of ‘Clickable’ Bacterial Autoinducing Probes: Unanticipated Effects on Mammalian Cell Activation.” Bioorg. Med. Chem. Lett. 2011, 21, 2702-2705.

14. Garner, A. L.; Janda, K. D. “Shedding Light on the Ghrelin/GOAT Metabolism Saga.” ChemBioChem 2011, 12, 523-525.

13. Garner, A. L.; Janda, K. D. “Protein-Protein Interactions and Cancer: Targeting the Central Dogma.” Curr. Topics Med. Chem. 2011, 11, 258-280.

12. Garner, A. L.; Janda, K. D. “cat-ELCCA: A Robust Method to Monitor the Fatty Acid Acyltransferase Activity of Ghrelin O-Acyltransferase (GOAT).” Angew. Chem., Int. Ed. 2010, 49, 9630-9634.

Featured in C&E News 2010, September 27 issue, pg. 15.

11. Gloeckner, C.; Garner, A. L.; Mersha, F.; Oksov, Y.; Tricoche, N.; Eubanks, L. M.; Lustigman, S.; Kaufmann, G. F.; Janda, K. D. “Repositioning of an Existing Drug for the Neglected Tropical Disease Onchocerciasis.” Proc. Natl. Acad. Sci., U. S. A. 2010, 107, 3424-3429.

Featured in Science Now: http://news.sciencemag.org/sciencenow/2010/02/09-01.html.
Featured in C&E News 2010, February 22 issue, pg. 35.

Graduate Publications

10. Koide, K.; Osman, S.; Garner, A. L.; Song, F.; Dixon, T.; Greenberger, J. S.; Epperly, M. W. “The Use of 3,5,4’-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from g-Irradiation-Induced Death.” ACS Med. Chem. Lett. 2011, 2, 270-274.

Featured in Newsweek: http://www.newsweek.com/2011/05/15/newsbeast-health.html.

9. Garner, A. L.; St. Croix, C. M.; Pitt, B. R.; Leikauf, G. D.; Ando, S.; Koide, K. “Specific Fluorogenic Probes for Ozone in Biological and Atmospheric Samples.” Nat. Chem. 2009, 1, 316-321.

Featured by the RSC: http://www.rsc.org/chemistryworld/News/2009/May/31050901.asp.
Featured in Nature Methods: http://www.nature.com/nmeth/journal/v6/n8/full/nmeth0809-557.html.

8. Garner, A. L.; Song, F.; Koide, K. “Enhancement of a Catalysis-Based Fluorometric Detection Method for Palladium through Rational Fine-Tuning of the Palladium Species.” J. Am. Chem. Soc. 2009, 131, 5163-5171.

7. Uchida, T.; Mills, K. L.; Kuo, C-H.; Roh, W.; Tung, Y-C.; Garner, A. L.; Koide, K.; Thouless, M. D.; Takayama, S. “External Compression-Induced Fracture Patterning on the Surface of Poly(dimethylsiloxane) Cubes and Microspheres.” Langmuir 2009, 25, 3102-3107.

6. Garner, A. L.; Koide, K. “Studies of Fluorogenic Probe for Palladium and Platinum Leading to a Palladium-Specific Detection Method.” Chem. Commun. 2009, 86-88.

5. Garner, A. L.; Koide, K. “Fluorescent Method for Platinum Detection in Buffers and Serum for Occupational Hazard and Cancer Medicine.” Chem. Commun. 2009, 83-85.

4. Garner, A. L.; Koide, K. “Oxidation State-Specific Fluorescent Method for Palladium(II) and Platinum(IV) Based on the Catalyzed Aromatic Claisen Rearrangement.” J. Am. Chem. Soc. 2008, 130, 16472-16473.

3, Koide, K.; Song, F.; de Groh, E. D.; Garner, A. L.; Mitchell, V. D.; Davidson, L. A.; Hukriede, N. A. “Scalable and Concise Synthesis of Dichlorofluorescein Derivatives Displaying Tissue Permeation in Live Zebrafish Embryos.” ChemBioChem 2008, 9, 214-218.

2. Garner, A. L.; Koide, K. “Solid-Phase Olefin Cross-Metathesis Promoted by a Linker.” Org. Lett. 2007, 9, 5235-5238.

Featured in C&E News 2007, November 26 issue, pg. 8.

1. Song, F.; Garner, A. L.; Koide, K. “A Highly Sensitive Fluorescent Sensor for Palladium Based on the Allylic Oxidative Insertion Mechanism.” J. Am. Chem. Soc. 2007, 129, 12354-12355.

Featured in C&E News 2007, October 1 issue, pg. 30.