Garner Laboratory
Merging innovations in chemical biology with academic drug discovery
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Research
The Garner Laboratory is an interdisciplinary group using chemical biology, medicinal chemistry and molecular and cellular biology approaches to investigate the high-risk/high-reward areas of targeting microRNAs, RNA-protein and protein-protein interactions for probe and drug discovery. These efforts are part of our larger interest in investigating the role of translational control in human diseases, which is dysregulated in a number of human diseases, yet remains underexplored for therapeutic development. The anticipated outcome of these studies is the validation of RNA biology-related targets for future drug discovery efforts and the betterment of human health.
Latest News
Welcome Gina and Anupama as new rotation students in the lab!
January 2024
Congrats to Dalia on acceptance of her mRNA-protein interaction RiPCA manuscript!
November 2023
Welcome Sierra and Yao as new rotation students in the lab!
October 2023
Congrats to Rachel for being awarded a best poster award at the ICBS Meeting!
September 2023
Congrats to Maurinne for being awarded a Michigan Pioneer Postdoctoral Fellowship!
September 2023
Welcome Marc, Nick, and Ileanexis as new rotation students in the lab!
August 2023
Congrats to Dalia on being awarded a best student poster award at the Medicinal Chemistry Gordon Research Conference!
August 2023
The lab is awarded a Breakthrough Science Initiative Award from the Ono Pharma Foundation!
July 2022
Congrats to Yihao on successfully defending his thesis!
June 2023
Congrats to Rachel on passing candidacy!
June 2023
Welcome Maurinne as a new post doc in the lab!
May 2023
Congrats to Dalia on being awarded a 2023-2024 ACS Division of Medicinal Chemistry Predoctoral Fellowship!
April 2023
Welcome Brandon as a new graduate student in the lab!
March 2023
Congrats to Gabriela on passing her candidacy exam!
March 2023
Welcome Evelyn as a new undergraduate student in the lab!
January 2023
Congrats to Rachel on her successful PhD defense!
November 2022
The lab is awarded a Catalyst Award from the Dr. Ralph and Marian Falk Medical Research Trust for a stealth-mode project in RNA-targeted drug discovery!
November 2022
Congrats to Yihao on winning an outstanding graduate research award at the Med Chem retreat!
November 2022
Congrats to Sydney on acceptance of her RiPCA 2.0 manuscript!
October 2022
Congrats to Gabriela for receiving an NIH Supplement Fellowship for her work investigating eIF4E!
September 2022
Welcome Brandon as a new Med Chem rotation student in the lab!
September 2022
Good luck to Arya as she begins her first year in the PhD Program in Chemical Biology!
August 2022
Congrats to Sydney on her successful PhD defense!
August 2022
Good luck to Dalia as she heads to San Diego to complete a summer internship at Trotana Therapeutics!
June 2022
Welcome Casey as a new undergraduate researcher in the lab!
June 2022
Congrats to Jose and Dalia on passing candidacy this semester!
May 2022
Congrats to Maddie on her graduation from UM!
May 2022
Welcome Gabriela as a new Garner lab graduate student!
April 2022
Welcome Andrea as a new technician in the lab!
March 2022
Welcome Gabriela as a new rotation student in the lab!
March 2022
Welcome Rachel as a new Garner lab graduate student!
March 2022
The lab is awarded Michigan Drug Discovery grant to continue our work in discovering new natural products targeting oncogenic pre-microRNAs!
February 2022
Congrats to Sydney on acceptance of her RiPCA protocol manuscript!
January 2022
Welcome Kate and Sahar as new rotation students in the lab!
January 2022
Congrats to Prof. Garner for being awarded the 2022 David W. Robertson Award from the ACS Division of Medicinal Chemistry!
November 2021
Welcome Robin as a new Masters student in the lab!
September 2021
Welcome Rachel and Alex as new rotation students in the lab!
August 2021
Congrats to Dalia for receiving a Cellular Biotechnology Training Program fellowship!
August 2021
Congrats to Jose for receiving an NIH Supplement Fellowship for his work in targeting cellular RNAs!
August 2021
RiPCA is highlighted in Promega Connections: https://www.promegaconnections.com/rna-protein-interactions-garner/!
May 2021
Congrats to Emilio on receiving the 2021 Merck Research Award for Underrepresented Chemists of Color!
May 2021
Welcome Dalia and Jose as new grad students in the lab!
April 2021
Congrats to Emilio on receiving the 2021 Scarborough Graduate/PostGraduate Award for Excellence in Medicinal Chemistry from the ACS MEDI division!
March 2021
Congrats to undergrad researcher Maddie Hinkley on receiving a NIH summer research fellowship to study in Dr. Jordan Meier's lab!
March 2021
Congrats to Team miRNA on acceptance of our first publication using natural products to identify new RNA binding scaffolds!
March 2021
Welcome Shruti as a new post doc in the lab!
February 2021
Welcome Noha as a new MS student in the lab!
January 2021
The lab is awarded an Upjohn Award from the College of Pharmacy to start a new project in targeting RNAs with small molecules!
January 2021
Welcome Jose as a winter semester rotation student in the lab!
January 2021
Congrats to Sydney and Dan on acceptance of their RiPCA manuscript in RSC Chem. Biol.!
June 2020
Welcome Dalia, Brad and Tommy as fall semester rotation students in the lab!
September 2020
Welcome Gabriela as a new PREP student in the lab!
August 2020
The Lab is awarded a new R01 grant for using our chemoproteomic approach to identify new 4E-BP1 kinases!
August 2020
Our latest work describing our continuing efforts in developing 4E-BP1 stapled peptides has now been accepted in Eur. J. Med. Chem.!
July 2020
Congrats to Yihao on passing his candidacy exam!
June 2020
Our manuscript describing our assay for detection of pre-miRNA-protein interactions in live cells is now up on bioRxiv!
June 2020
Congrats to Rachel for receiving a NIH F31 Predoctoral Fellowship!
June 2020
Congrats to Prof. Garner on her promotion to Associate Professor with tenure!
May 2020
Congrats to Sydney for receiving a 2020-2021 ACS Division of Medicinal Chemistry Predoctoral Fellowship!
March 2020
Congrats to Sydney for receiving a Travel Award to attend the 2020 RNA Society Meeting!
February 2020
Congrats to Dylan and Arya on acceptance of their 4E-BP1/CDK4/Mitosis manuscript!
December 2019
Congrats to Emily and Dylan on acceptance of their SART3 manuscript!
November 2019
Check out Prof. Garner's new commentary on RNA-targeted drug discovery in Future Medicinal Chemistry
October 2019
The Lab is awarded a new R01 grant for developing a live-cell RNA-protein interaction assay!
September 2019
Welcome Maddie and Julia as a new Garner lab undergraduate students!
September 2019
Welcome Emilio as a new Garner lab post doc!
August 2019
Welcome Yihao as a new Garner lab graduate student!
June 2019
Congrats to James, Erin and Arya on the acceptance of their E/Z 4E-BP1 stapled peptide manuscript!
June 2019
Congrats to Rachel for passing candidacy!
June 2019
Congrats to Emily and Dan on acceptance of their new RNA-protein interaction assay manuscript!
June 2019
Congrats to James, Erin and Arya on the acceptance of their 4E-BP1 stapled peptide manuscript!
April 2019
Congrats to the RNA team on the acceptance of their tetracycline and cat-ELCCA NPE discovery manuscripts!
April 2019
Congrats to Sydney for passing candidacy!
February 2019
Congrats to Dylan for successfully defending his PhD thesis!
February 2019
Congrats to Dylan and Arya on the acceptance of their PhAXA manuscript!
February 2019
Congrats to Tanpreet and Arya on the acceptance of their eIF4E degrader paper!
January 2019
Congrats to Erin for completing her PhD!
December 2018
Congrats to Oleta and Tanpreet on the acceptance of their new assay paper!
August 2018
Congrats to James and Oleta as the 2nd and 3rd PhDs from the lab!
July and August 2018
Congrats to Dan and Tanpreet on the acceptance of their Lin28 cat-ELCCA paper!
May 2018
Welcome Rachel and Sydney as new Garner Lab grad students!
April 2018
Congrats to Dan as the first PhD from the Lab!
March 2018
Congrats to Dylan on receiving a Rackham Predoctoral Fellowship!
February 2018
Congrats to James on the acceptance of his PPI cat-ELCCA paper!
November 2017
Congrats to Dan on the acceptance of his miRNA HTS paper!
June 2017
The Lab is awarded a pilot grant from the UM Cancer Center for our 4E-BP1 chemoproteomic work!
May 2017
The Lab is awarded a pilot grant from the UM Center for the Discovery of New Medicines for targeting eIF4E PPIs!
January 2017
The Lab is awarded funding from the Dr. Ralph and Marion Falk Medical Research Trust for targeting miRNAs!
November 2016
The Lab is awarded its second R01 for our 4E-BP mimetic work!
June 2016
Congrats to Dan on the acceptance of his IEDDA-based cat-ELCCA paper!
May 2016
The Lab is awarded its first R01 for our miRNA assay work!
March 2016
