Research

The Garner Laboratory is an interdisciplinary group using chemical biology, medicinal chemistry and molecular and cellular biology approaches to investigate the high-risk/high-reward areas of targeting microRNAs, RNA-protein and protein-protein interactions for probe and drug discovery. These efforts are part of our larger interest in investigating the role of translational control in human diseases, which is dysregulated in a number of human diseases, yet remains underexplored for therapeutic development. The anticipated outcome of these studies is the validation of mRNA translation-related targets for future drug discovery efforts and the betterment of human health.

Latest News

The Lab is awarded a new R01 grant for using our chemoproteomic approach to identify new 4E-BP1 kinases!

August 2020

Our latest work describing our continuing efforts in developing 4E-BP1 stapled peptides has now been accepted in Eur. J. Med. Chem.!

July 2020

Congrats to Yihao on passing his candidacy exam!

June 2020

Our manuscript describing our assay for detection of pre-miRNA-protein interactions in live cells is now up on bioRxiv!

June 2020

Congrats to Rachel for receiving a NIH F31 Predoctoral Fellowship!

June 2020

Congrats to Prof. Garner on her promotion to Associate Professor with tenure!

May 2020

 

Congrats to Sydney for receiving a 2020-2021 ACS Division of Medicinal Chemistry Predoctoral Fellowship!

March 2020

Congrats to Sydney for receiving a Travel Award to attend the 2020 RNA Society Meeting!

February 2020

Congrats to Dylan and Arya on acceptance of their 4E-BP1/CDK4/Mitosis manuscript!

December 2019

Congrats to Emily and Dylan on acceptance of their SART3 manuscript!

November 2019

Check out Prof. Garner's new commentary on RNA-targeted drug discovery in Future Medicinal Chemistry

October 2019

The Lab is awarded a new R01 grant for developing a live-cell RNA-protein interaction assay!

September 2019

Welcome Maddie and Julia as a new Garner lab undergraduate students!

September 2019

Welcome Emilio as a new Garner lab post doc!

August 2019

Welcome Yihao as a new Garner lab graduate student!

June 2019

Congrats to James, Erin and Arya on the acceptance of their E/Z 4E-BP1 stapled peptide manuscript!

June 2019

Congrats to Rachel for passing candidacy!

June 2019

Congrats to Emily and Dan on acceptance of their new RNA-protein interaction assay manuscript!

June 2019

Congrats to James, Erin and Arya on the acceptance of their 4E-BP1 stapled peptide manuscript!

April 2019

Congrats to the RNA team on the acceptance of their tetracycline and cat-ELCCA NPE discovery manuscripts!

April 2019

Congrats to Sydney for passing candidacy!

February 2019

Congrats to Dylan for successfully defending his PhD thesis!

February 2019

Congrats to Dylan and Arya on the acceptance of their PhAXA manuscript!

February 2019

Congrats to Tanpreet and Arya on the acceptance of their eIF4E degrader paper!

January 2019

Congrats to Erin for completing her PhD!

December 2018

Congrats to Oleta and Tanpreet on the acceptance of their new assay paper!

August 2018

Congrats to James and Oleta as the 2nd and 3rd PhDs from the lab!

July and August 2018

Congrats to Dan and Tanpreet on the acceptance of their Lin28 cat-ELCCA paper!

May 2018

Welcome Rachel and Sydney as new Garner Lab grad students!

April 2018

Congrats to Dan as the first PhD from the Lab!

March 2018

Congrats to Dylan on receiving a Rackham Predoctoral Fellowship!

February 2018

Congrats to James on the acceptance of his PPI cat-ELCCA paper!

November 2017

Congrats to Dan on the acceptance of his miRNA HTS paper!

June 2017

 

The Lab is awarded a pilot grant from the UM Cancer Center for our 4E-BP1 chemoproteomic work!

May 2017

The Lab is awarded a pilot grant from the UM Center for the Discovery of New Medicines for targeting eIF4E PPIs!

January 2017

The Lab is awarded funding from the Dr. Ralph and Marion Falk Medical Research Trust for targeting miRNAs!

November 2016

The Lab is awarded its second R01 for our 4E-BP mimetic work!

June 2016

Congrats to Dan on the acceptance of his IEDDA-based cat-ELCCA paper!

May 2016

 

The Lab is awarded its first R01 for our miRNA assay work!

March 2016