The Garner Laboratory is an interdisciplinary group using chemical biology, medicinal chemistry and molecular and cellular biology approaches to investigate the high-risk/high-reward areas of targeting microRNAs, RNA-protein and protein-protein interactions for probe and drug discovery. These efforts are part of our larger interest in investigating the role of translational control in human diseases, which is dysregulated in a number of human diseases, yet remains underexplored for therapeutic development. The anticipated outcome of these studies is the validation of mRNA translation-related targets for future drug discovery efforts and the betterment of human health.
RiPCA is highlighted in Promega Connections: https://www.promegaconnections.com/rna-protein-interactions-garner/!
Congrats to Emilio on receiving the 2021 Merck Research Award for Underrepresented Chemists of Color!
Welcome Dalia and Jose as new grad students in the lab!
Congrats to Emilio on receiving the 2021 Scarborough Graduate/PostGraduate Award for Excellence in Medicinal Chemistry from the ACS MEDI division!
Congrats to undergrad researcher Maddie Hinkley on receiving a NIH summer research fellowship to study in Dr. Jordan Meier's lab!
Congrats to Team miRNA on acceptance of our first publication using natural products to identify new RNA binding scaffolds!
Welcome Shruti as a new post doc in the lab!
Welcome Noha as a new MS student in the lab!
The lab is awarded an Upjohn Award from the College of Pharmacy to start a new project in targeting RNAs with small molecules!
Welcome Jose as a winter semester rotation student in the lab!
Congrats to Sydney and Dan on acceptance of their RiPCA manuscript in RSC Chem. Biol.!
Welcome Dalia, Brad and Tommy as fall semester rotation students in the lab!
Welcome Gabriela as a new PREP student in the lab!
The Lab is awarded a new R01 grant for using our chemoproteomic approach to identify new 4E-BP1 kinases!
Our latest work describing our continuing efforts in developing 4E-BP1 stapled peptides has now been accepted in Eur. J. Med. Chem.!
Congrats to Yihao on passing his candidacy exam!
Our manuscript describing our assay for detection of pre-miRNA-protein interactions in live cells is now up on bioRxiv!
Congrats to Rachel for receiving a NIH F31 Predoctoral Fellowship!
Congrats to Prof. Garner on her promotion to Associate Professor with tenure!
Congrats to Sydney for receiving a 2020-2021 ACS Division of Medicinal Chemistry Predoctoral Fellowship!
Congrats to Sydney for receiving a Travel Award to attend the 2020 RNA Society Meeting!
Congrats to Dylan and Arya on acceptance of their 4E-BP1/CDK4/Mitosis manuscript!
Congrats to Emily and Dylan on acceptance of their SART3 manuscript!
Check out Prof. Garner's new commentary on RNA-targeted drug discovery in Future Medicinal Chemistry
The Lab is awarded a new R01 grant for developing a live-cell RNA-protein interaction assay!
Welcome Maddie and Julia as a new Garner lab undergraduate students!
Welcome Emilio as a new Garner lab post doc!
Welcome Yihao as a new Garner lab graduate student!
Congrats to James, Erin and Arya on the acceptance of their E/Z 4E-BP1 stapled peptide manuscript!
Congrats to Rachel for passing candidacy!
Congrats to Emily and Dan on acceptance of their new RNA-protein interaction assay manuscript!
Congrats to James, Erin and Arya on the acceptance of their 4E-BP1 stapled peptide manuscript!
Congrats to the RNA team on the acceptance of their tetracycline and cat-ELCCA NPE discovery manuscripts!
Congrats to Sydney for passing candidacy!
Congrats to Dylan for successfully defending his PhD thesis!
Congrats to Dylan and Arya on the acceptance of their PhAXA manuscript!
Congrats to Tanpreet and Arya on the acceptance of their eIF4E degrader paper!
Congrats to Erin for completing her PhD!
Congrats to Oleta and Tanpreet on the acceptance of their new assay paper!
Congrats to James and Oleta as the 2nd and 3rd PhDs from the lab!
July and August 2018
Congrats to Dan and Tanpreet on the acceptance of their Lin28 cat-ELCCA paper!
Welcome Rachel and Sydney as new Garner Lab grad students!
Congrats to Dan as the first PhD from the Lab!
Congrats to Dylan on receiving a Rackham Predoctoral Fellowship!
Congrats to James on the acceptance of his PPI cat-ELCCA paper!
Congrats to Dan on the acceptance of his miRNA HTS paper!
The Lab is awarded a pilot grant from the UM Cancer Center for our 4E-BP1 chemoproteomic work!
The Lab is awarded a pilot grant from the UM Center for the Discovery of New Medicines for targeting eIF4E PPIs!
The Lab is awarded funding from the Dr. Ralph and Marion Falk Medical Research Trust for targeting miRNAs!
The Lab is awarded its second R01 for our 4E-BP mimetic work!
Congrats to Dan on the acceptance of his IEDDA-based cat-ELCCA paper!
The Lab is awarded its first R01 for our miRNA assay work!